Impaired Immune Response in Obesity (leptin) + Herd Immunity: USA May Have a Problem



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Scientists find lean subjects made protective antibodies after infection while obese subjects did not make protective antibodies—they made maladaptive autoantibodies instead. Researchers speculate that leptin plays a role in skewing the immune response toward autoimmunity after infection.

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—————————————–Show Notes————————————–

0:00 Intro
0:09 Endemic Virus
0:59 Obese Don’t Make Protective Antibodies
1:15 Obese people make autoantibodies
1:40 Leptin and Fat on Fire
2:40 Leptin exacerbates inflammation, autoimmunity
3:13 Study we’re discussing
3:49 Make Americans Healthy Again
4:35 Blood Work MasterClass
5:30 Daniela Frasca, PhD: Obesity Hinders Immune System Response
6:10 Antibodies and BMI, C-Reactive Protein
6:43 Metainflammation and Inflammaging
7:15 Blood sugar and inflammation
8:13 Leptin and immunity
9:29 Summary of Study: immune tolerance breakdown
11:30 Lifestyle matters
12:30 Antibodies directed at fat tissue
12:52 Omega-6 Oils, Seed Oils & autoimmunity
13:50 Excess deaths related to heart disease on the rise
14:42 Image: CRP and autoantibodies
15:39 New study summary
16:21 Italy Research from fat cell spill over
16:58 Obesity is an autoimmune disease
17:05 Change your habits
17:47 Image: Behavior model
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34 Comments

  1. Why are they vaccinated kids. For the last two years kids didn’t get sick . I know they wanted vaccines to stop the infection and transmission but they failed ( or it’s working as planned ) if vaccines only possibly help prevent hospitalization and kids seldom get hospitalized why expose them to the dangers.? This is a pandemic of lack of critical thinking.

  2. Great video! Also would like to add that chronic mold exposure can also cause weight gain for some people. "Chronic mold exposure activates a part of the immune system (innate immune system) which leads to damage to the Leptin receptors in the brain. This Leptin resistance leads to weight gain."
    Many homes, buildings and schools are moldy. Mold is a biotoxin. Indoor air quality is very important to your health but is often ignored.

  3. I’ve had folks (mainly family) comment on my weight loss and my thinner body negatively which several of them are overweight or obese, our society is so accustomed to the Obesity epidemic as normal a lot of people think if you’re not plump and chunky or whatever that you are sick and unhealthy, people complain about fat shaming what about skinny shaming?

  4. Does anyone have a clear answer on it fasting causes you to lose muscle? Like if I was to do a 4-5 day fast? I'm not Rambo or anything but I do have some tone and don't want to lose it lol.

  5. You are right I was just lucky that I survived the Covid infection even if I am obese with hypertension and old, I believe it was not my immune system that help me survived but with the helped of the Devine intervention

  6. No, the real problem is that people will call you "fatphobic" if you point this out or make this argument. And they will ha e credibility with certian circles by making such an "argument". And they will blind themselves to the actual evidence. THAT is the real problem lol.

  7. 😂😂😂😂 Dude did you actually read this paper and the other ones this research group put out? Their number of participants is so small and their findings so correlative, BOTH problems identified by researchers, your headline and “opinion” from their study is serious overreach i.e. BAD conclusions from currently limited science. These researchers are trying to get GRANT MONEY to see if their random analyses which found some odd things means anything 5 years down the road….. Right now there is coincidence and nothing much else…. and here you are speaking all sorts of authoritative BS dooming and glooming every fat person in the nation to promote and market your brand 😂😂😂😂😂😂 Get a life High Intensity Health. If this is how you usually interpret science you’re opinions are seriously questionable….no substance. Run on and HIIT your day hard 😂😂😂😂😂

  8. I've been doing high intensity excersize since before everyone was blabbing about how great they are on an podcast or on youtube or on some place on social media.
    Long before there was any social media I was doing this shit.

    Whats the moral of the story? I learned that people are mostly stupid and lazy until getting up early and excersizing becomes trendy.

    I'd sit at the office at my desk eating an apple and some smart ass would walk by and comment how I like to 'eat health food', all I was doing was eating an apple.

    Annoying video, annoying comment section.

  9. I moved this year specifically to be close to the gym because I KNOW I'm a lazy ass. so now the gym is 4 minutes of walking away. This stuff is scary so hope it works

  10. Im 42 always been 149 doesn't move no matter what I eat but one thing I do is eat late and go to bed .. guess thats really bad for me even though I never been sick my whole life?

  11. I admire how you refer to us overweight people, with respect but still pointing out the impact on health. I am on my way to recover my health. I have already lost 60 pounds. I try to find verified sources of information to keep me motivated and going. Thanks for your amazing help

  12. Yes this is a cold hybridized with with virulence factors to make it a super cold. so it is as contagious as a cold stain we have no immunity from and the hard hitting power of the flu. So it fast and deadly to people whose immune system is slower and weaker. This guy is correct that obesity is high for comorbidity, it is second only to increased age which none of us can change. But most can lose weight so, why are doctors not getting the message out to give us a chance to improve our outcome before we get it? Who's interest do they serve? If we follow the money we would know.

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